A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress.

ABSTRACT: The maintenance of cellular homeostasis in living organisms requires a balance between anabolic and catabolic reactions. Macroautophagy (autophagy herein) is determined as one of the major catabolic reactions. Autophagy is an evolutionarily conserved stress response pathway that is activated by various insults including DNA damage. All sorts of damage to DNA potentially cause loss of genetic information and trigger genomic instability. Most of these lesions are repaired by the activation of DNA damage response following DNA repair mechanisms. Here we describe, a novel protein complex containing the autophagy protein ATG5 and the non-homologous end-joining repair system proteins. We discovered for the first time that ATG5 interacted with both Ku80 (XRCC5) and Ku70 (XRCC6). This novel intera

SUBMITTER: Demirbag-Sarikaya S 

PROVIDER: S-EPMC9114114 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature