Dataset Information

Biometric Determinants of Epithelial Thickness Profile Across a Wide Range of Refractive Errors.

ABSTRACT:

Introduction

To evaluate the corneal epithelial thickness (CET) profiles and their correlations with axial length (AL) and anterior corneal radius of curvature (Rm F) across different refractive error groups.

Methods

A total of 1225 eyes of 616 normal patients were included. CET mapping, AL, and Rm F were obtained using spectral-domain optical coherence tomography, optical biometry, and Scheimpflug corneal tomography, respectively. In the CET map, one central (2 mm), eight paracentral (2-5 mm), and eight peripheral (5-6 mm) quadrants were evaluated separately. The subjects were divided into four groups based on their refractive status: hyperopia (spherical equivalent [SE] ≥ +0.50 D), emmetropia (SE > -0.50 D and < +0.50 D), low myopia (SE ≤ -0.50 D and > -3.0 D), and moderate-high myopia (SE ≤ -3.0 D) groups. Linear mixed model analysis with Bonferroni correction was used to compare CET according to refractive error groups. The correlations between the CET profile and the AL and Rm F were analyzed.

Results

The central CET was 53.7 ± 3.3 μm in hyperopia (n = 34), 53.2 ± 2.9 μm in emmetropia (n = 353), 52.8 ± 2.9 μm in low myopia (n = 677), and 52.0 ± 3.1 μm in moderate-high myopia (n = 161). Although thinning was observed in CET in all quadrants from hyperopia to moderate-high myopia, it was only significant in the superior and superonasal quadrants at the 2-5 mm and 5-6 mm-diameter rings. While AL and CET were significantly positively correlated (r range 0.17-0.28) in the moderate-high myopia group, Rm F and CET were significantly positively correlated (r range 0.08-0.10) in the low and moderate-high myopia groups.

Conclusion

CET varied according to different refractive error groups and was positively correlated with AL and Rm F, particularly in the moderate-high myopia group.

SUBMITTER: Ozalp O

PROVIDER: S-EPMC9114216 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Biometric Determinants of Epithelial Thickness Profile Across a Wide Range of Refractive Errors.

Ozalp Onur O Atalay Eray E

Ophthalmology and therapy 20220314 3

<h4>Introduction</h4>To evaluate the corneal epithelial thickness (CET) profiles and their correlations with axial length (AL) and anterior corneal radius of curvature (Rm F) across different refractive error groups.<h4>Methods</h4>A total of 1225 eyes of 616 normal patients were included. CET mapping, AL, and Rm F were obtained using spectral-domain optical coherence tomography, optical biometry, and Scheimpflug corneal tomography, respectively. In the CET map, one central (2 mm), eight paracen ...[more]

PMID: 35286628

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Project description:PurposeChanges in retinal thickness are common in various ocular diseases. Transverse magnification due to differing ocular biometrics, in particular axial length, affects measurement of retinal thickness in different regions. This study evaluated the effect of axial length and refractive error on measured macular thickness in two community-based cohorts of healthy young adults.MethodsA total of 2160 eyes of 1247 community-based participants (18-30 years; 23.4% myopes, mean axial length = 23.6mm) were included in this analysis. Macular thickness measurements were obtained using a spectral-domain optical coherence tomography (which assumes an axial length of 24.385mm). Using a custom program, retinal thickness data were extracted at the 9 Early Treatment of Diabetic Retinopathy Study (ETDRS) regions with and without correction for transverse magnificent effects, with the corrected measurements adjusting according to the participant's axial length. Linear mixed models were used to analyse the effect of correction and its interaction with axial length or refractive group on retinal thickness.ResultsThe raw measures (uncorrected for axial length) underestimated the true retinal thickness at the central macula, while overestimating at most non-central macular regions. There was an axial length by correction interaction effect in all but the nasal regions (all p<0.05). For each 1mm increase in axial length, the central macular thickness is overestimated by 2.7-2.9μm while thicknesses at other regions were underestimated by 0.2-4.1μm. Based on the raw thickness measurements, myopes have thinner retinas than non-myopes at most non-central macular. However, this difference was no longer significant when the corrected data was used.ConclusionIn a community-based sample, the raw measurements underestimate the retinal thickness at the central macula and overestimate the retinal thickness at non-central regions of the ETDRS grid. The effect of axial length and refractive error on retinal thickness is reduced after correcting for transverse magnification effects resulting from axial length differences.

Project description:BackgroundRefractive errors are one of the most common ocular conditions among children and adolescents, with myopia showing an increasing prevalence and early onset in this population. Recent studies have identified a correlation between refractive errors and ocular biometric parameters.MethodsA systematic search was conducted in electronic databases including PubMed, EMBASE, Cochrane Library, Web of Science, and Medline from January 1, 2012, to May 1, 2023. Various ocular biometric parameters were summarized under different refractive states, including axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), corneal curvature (CC), Corneal curvature radius (CR),axial length-to-corneal radius ratio (AL/CR ratio), choroidal thickness (ChT), retinal thickness (RT), retinal nerve fiber layer thickness (RNFL), and retinal blood density (VD). The differences in these parameters among different refractive states were analyzed using Stata software with fixed or random-effects models, taking into account the assessed heterogeneity level.ResultsThis meta-analysis included a total of 69 studies involving 128,178 eyes, including 48,795 emmetropic eyes, 60,691 myopic eyes, 13,983 hyperopic eyes, 2,040 low myopic eyes, 1,201 moderate myopic eyes, and 1,468 high myopic eyes. The results of our study demonstrated that, compared to the control group (emmetropic group), the myopic group and low, moderate, and high myopic groups showed significant increases in AL, AL/CR ratio, and ACD, while the hyperopic group exhibited significant decreases. Compared to the control group, the myopic group had a significantly increase for CC, while CR, CCT, perifoveal RT, subfoveal ChT, foveal ChT, parafoveal ChT, perifoveal (except nasal) ChT, and pRNFL (except temporal) significantly decreased. Compared to the control group, the hyperopic group had a significantly increase for subfoveal ChT, foveal ChT, parafoveal ChT, perifoveal ChT, and nasal pRNFL. Compared to the control group, the low and moderate myopic groups had a significantly decreases for the CCT, parafoveal RT (except nasal), perifoveal RT (except nasal), and pRNFL (except superior and temporal). Compared to the control group, the high myopic group had a significantly increase for CR, while LT, perifoveal ChT (except nasal), parafoveal RT, perifoveal RT, and pRNFL (except temporal) had significant decreased.ConclusionThe changes of ocular biometric parameters in children and adolescents are closely related to refractive errors. Ocular biometric parameters devices, as effective non-invasive techniques, provide objective biological markers for monitoring refractive errors such as myopia.

Dataset Information

Biometric Determinants of Epithelial Thickness Profile Across a Wide Range of Refractive Errors.

Introduction

Methods

Results

Conclusion

Publications

Biometric Determinants of Epithelial Thickness Profile Across a Wide Range of Refractive Errors.

Similar Datasets

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