Immunohistochemical and mutational status of telomerase reverse transcriptase in conjunctival squamous cell carcinoma.

ABSTRACT:

Purpose

Mutations in human telomerase reverse transcriptase (TERT) are associated with increased telomerase activity in cutaneous melanomas. Conjunctival squamous cell carcinoma, also referred to as ocular surface squamous cell carcinoma, is cancer on the surface of the eye. Recent studies have identified UV signat`ure mutations in TERT promoters in ocular melanoma and ocular surface squamous neoplasia. However, its immunohistochemical status has not been reported in ocular surface squamous cell carcinoma. This study aimed to explore the immunohistochemical and mutational status of TERT in ocular surface SCC.

Methods

The immunohistochemical expression of TERT and mutational status of TERT promoter was evaluated in 19 ocular surface squamous cell carcinoma cases. Conjunctival

SUBMITTER: Jayaraj P 

PROVIDER: S-EPMC9114615 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature