Facilitation of Reparative Dentin Using a Drug Repositioning Approach With 4-Phenylbutric Acid.

ABSTRACT: For hard tissue formation, cellular mechanisms, involved in protein folding, processing, and secretion play important roles in the endoplasmic reticulum (ER). In pathological and regeneration conditions, ER stress hinders proper formation and secretion of proteins, and tissue regeneration by unfolded protein synthesis. 4-Phenylbutyric acid (4PBA) is a chemical chaperone that alleviates ER stress through modulation in proteins folding and protein trafficking. However, previous studies about 4PBA only focused on the metabolic diseases rather than on hard tissue formation and regeneration. Herein, we evaluated the function of 4PBA in dentin regeneration using an exposed pulp animal model system via a local delivery method as a drug repositioning strategy. Our results showed altered morphologi

SUBMITTER: Lee ES 

PROVIDER: S-EPMC9114641 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature