SPLUNC1 is a negative regulator of the Orai1 Ca²⁺ channel.

ABSTRACT: Orai1 is a ubiquitously-expressed plasma membrane Ca²⁺ channel that is involved in store-operated Ca²⁺ entry (SOCE): a fundamental biological process that regulates gene expression, the onset of inflammation, secretion, and the contraction of airway smooth muscle (ASM). During SOCE, Ca²⁺ leaves the endoplasmic reticulum, which then stimulates a second, amplifying wave of Ca²⁺ influx through Orai1 into the cytoplasm. Short Palate LUng and Nasal epithelial Clone 1 (SPLUNC1; gene name BPIFA1) is a multi-functional, innate defense protein that is highly abundant in the lung. We have previously reported that SPLUNC1 was secreted from epithelia, where it bound to and inhibited Orai1, leading to reduced SOCE and ASM relaxation. However, the underlying m

SUBMITTER: Wu T 

PROVIDER: S-EPMC9114653 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature