Gut Microbiome Composition Abnormalities Determined Using High-Throughput Sequencing in Children With Tic Disorder.

ABSTRACT:

Object

To investigate the distribution characteristics of gut microbiota in children with tic disorder (TD) and the possible role of these characteristics in the pathogenesis of TD.

Methods

The medical records of 28 children with TD treated at Wuxi Children's Hospital from January 1 to October 31, 2020, and 21 age-matched healthy children (controls) were included. The relative quantification of bacterial taxa was performed using 16S ribosomal RNA gene amplicon sequencing.

Results

There was no significant difference in the alpha diversity of gut microbiota between the TD and control groups. Analyses of beta diversity were able to differentiate the TD patients from the healthy controls based on their gut microbiota. At the phylum level, the two groups were mainly compos

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9114666 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature