Dataset Information

Neuropilin-1 Identifies a New Subpopulation of TGF-β-Induced Foxp3⁺ Regulatory T Cells With Potent Suppressive Function and Enhanced Stability During Inflammation.

ABSTRACT: CD4⁺Foxp3⁺ regulatory T cells (Tregs) play a crucial role in preventing autoimmunity and inflammation. There are naturally-derived in the thymus (tTreg), generated extrathymically in the periphery (pTreg), and induced in vitro culture (iTreg) with different characteristics of suppressiveness, stability, and plasticity. There is an abundance of published data on neuropilin-1 (Nrp-1) as a tTreg marker, but little data exist on iTreg. The fidelity of Nrp-1 as a tTreg marker and its role in iTreg remains to be explored. This study found that Nrp-1 was expressed by a subset of Foxp3⁺CD4⁺T cells in the central and peripheral lymphoid organs in intact mice, as well as in iTreg. Nrp-1⁺iTreg and Nrp-1^-iTreg were adoptively tra

SUBMITTER: Chen W

PROVIDER: S-EPMC9114772 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Dataset Information

Neuropilin-1 Identifies a New Subpopulation of TGF-β-Induced Foxp3⁺ Regulatory T Cells With Potent Suppressive Function and Enhanced Stability During Inflammation.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Neuropilin-1 Identifies a New Subpopulation of TGF-β-Induced Foxp3+ Regulatory T Cells With Potent Suppressive Function and Enhanced Stability During Inflammation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Neuropilin-1 Identifies a New Subpopulation of TGF-β-Induced Foxp3⁺ Regulatory T Cells With Potent Suppressive Function and Enhanced Stability During Inflammation.