Beneficial Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation for the Verbal Memory and Default Mode Network in Healthy Older Adults.

ABSTRACT: Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) is a non-invasive effective treatment for cognitive disorder, but its underlying mechanism of action remains unknown. The aim of this study was to explore the effect of a 2-week high-frequency (HF) active or sham 10 Hz rTMS on verbal memory in 40 healthy older adults. Resting-state functional magnetic resonance imaging (rs-fMRI) was used to measure functional connectivity (FC) within the default mode network (DMN). Verbal memory performance was evaluated using an auditory verbal learning test (AVLT). Additionally, we evaluated the relationship between memory improvement and FC changes within the DMN. The results revealed that HF-rTMS can enhance immediate recall and delayed recall of verbal me

SUBMITTER: Cui D 

PROVIDER: S-EPMC9114775 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature