Correlation Between Salivary Microbiome of Parotid Glands and Clinical Features in Primary Sjogren's Syndrome and Non-Sjogren's Sicca Subjects.

ABSTRACT: Recent studies have demonstrated that the oral microbiome in patients with Sjögren's syndrome (SS) is significantly different from that in healthy individuals. However, the potential role of the oral microbiome in SS pathogenesis has not been determined. In this study, stimulated intraductal saliva samples were collected from the parotid glands (PGs) of 23 SS and nine non-SS subjects through PG lavage and subjected to 16S ribosomal RNA amplicon sequencing. The correlation between the oral microbiome and clinical features, such as biological markers, clinical manifestations, and functional and radiological characteristics was investigated. The salivary microbial composition was examined using bioinformatic analysis to identify potential diagnostic biomarkers for SS. Oral microbial compositi

SUBMITTER: Kim D 

PROVIDER: S-EPMC9114876 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature