Comparative efficacy and safety of statins for osteoporosis: a study protocol for a systematic review and network meta-analysis.

ABSTRACT:

Introduction

Osteoporosis (OP) is a prevalent skeletal disease with high mortality and morbidity, followed by acute and chronic back pain, severe spinal deformity and dysfunction. First-line drugs for OP work through antiresorptive or anabolic mechanisms. Although with good efficacy, these drugs still have certain limitations in clinical application due to delivery routes, medication cycles and cost issues. Nowadays, statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) appear to be potentially promising drugs for OP. Despite the controversy, previous studies have shown the efficacy of statins in treating OP. Other studies have further indicated that the therapeutic effect of OP in statin-treated patients is dose dependent. However, scientists have not yet reached a

SUBMITTER: Xiong M 

PROVIDER: S-EPMC9115030 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature