Anti-spike IgG antibody kinetics following the second and third doses of BNT162b2 vaccine in nursing home residents.

ABSTRACT:

Background

Duration of post-vaccination protection against COVID-19 in nursing home (NH) residents is a critical issue. The objective of this study was to estimate the duration of the IgG(S) response to the mRNA BNT162b2 vaccine in NH residents with (COV-Yes) or without (COV-No) history of SARS-CoV-2 infection.

Methods

A 574 COV-Yes and COV-No NH residents were included in 2 cohorts: Main (n = 115, median age 87 years) or Confirmatory (n = 459, median age 89 years). IgG(S) quantification was carried out at three different time points following the BNT162b2 vaccine: three (1st) and seven (2nd) months after the 2nd dose, and 1 month after the 3rd dose (3rd quantification) in the Main cohort, and twice (2nd and 3rd) in the Confirmatory cohort. The seroneutralization capacity ac

SUBMITTER: Jeulin H 

PROVIDER: S-EPMC9115082 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature