Low antispike antibody levels correlate with poor outcomes in COVID-19 breakthrough hospitalizations.

ABSTRACT:

Background

While COVID-19 immunization programs attempted to reach targeted rates, cases rose significantly since the emergence of the delta variant. This retrospective cohort study describes the correlation between antispike antibodies and outcomes of hospitalized, breakthrough cases during the delta variant surge.

Methods

All patients with positive SARS-CoV-2 polymerase chain reaction hospitalized at Mayo Clinic Florida from 19 June 2021 to 11 November 2021 were considered for analysis. Cases were analyzed by vaccination status. Breakthrough cases were then analyzed by low and high antibody titers against SARS-CoV-2 spike protein, with a cut-off value of ≥132 U/ml. Outcomes included hospital length of stay (LOS), need for intensive care unit (ICU), mechanical ventilation,

SUBMITTER: Sanghavi DK 

PROVIDER: S-EPMC9115098 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature