Thrombosis pathways in COVID-19 vs. influenza-associated ARDS: A targeted proteomics approach.

ABSTRACT:

Background

Pulmonary embolism (PE) occurs in one-third of critically-ill COVID-19 patients. Although prior studies identified several pathways contributing to thrombogenicity, it is unknown whether this is COVID-19-specific or also occurs in ARDS patients with another infection.

Objective

To compare pathway activity among patients having COVID-19 with PE (C19PE+), COVID-19 without PE (C19PE-), and influenza-associated ARDS (IAA) using a targeted proteomics approach.

Methods

We exploited an existing biorepository containing daily plasma samples to carefully match C19PE+ cases to C19PE- and IAA controls on mechanical ventilation duration, PEEP, FiO2, and cardiovascular-SOFA (n = 15 per group). Biomarkers representing various thrombosis pathways were measured using proxi

SUBMITTER: Rademaker E 

PROVIDER: S-EPMC9115133 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature