Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations.

ABSTRACT:

Background

Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal tract is involved in the disease, with gut barrier dysfunction and gut microbiota alterations being related to disease severity. Whether these alterations persist and are related to long-term respiratory dysfunction remains unknown.

Methods

Plasma was collected during hospital admission and after 3 months from the NOR-Solidarity trial (n = 181) and analyzed for markers of gut barrier dysfunction and inflammation. At the 3-month follow-up, pulmonary function was assessed by measuring the diffusing capacity of the lungs for carbon monoxide (DL_CO ). Rectal swabs for gut microbiota analyses were collected (n = 97) and analy

SUBMITTER: Vestad B 

PROVIDER: S-EPMC9115297 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature