Evolution of pathological findings in surveillance biopsies of lung transplant recipients infected with SARS-CoV-2.

ABSTRACT:

Background

Previous reports of coronavirus disease 2019 (COVID-19) following lung transplantation generally described a grim prognosis, but these were anecdotal case series of symptomatic patients. A systematic study of the outcomes and pathology of SARS-CoV-2 infection in a large cohort of lung transplant patients is lacking.

Methods

To determine the histopathologic evolution of COVID-19 in lung transplant recipients, we identified all patients who underwent surveillance transbronchial biopsies at our institution, tested positive for SARS-CoV-2, and had multiple pathology specimens available for evaluation. Histology was reviewed and immunofluorescence for SARS-CoV-2 nucleocapsid protein was performed.

Results

Ten patients met inclusion criteria. Half (5/10) had inci

SUBMITTER: Wein AN 

PROVIDER: S-EPMC9115334 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature