Convalescent plasma for COVID-19: Donor demographic factors associated high neutralising antibody titres.

ABSTRACT:

Background

Convalescent plasma containing high levels of SARS-CoV-2 antibodies has been studied as a possible treatment for COVID-19. Better understanding of predictors of high antibody levels is needed for improving supply of high-quality therapeutic plasma.

Aims

We have evaluated demographic and clinical factors associated with the probability of a convalescent plasma donor having high SARS-CoV-2 IgG antibody levels.

Methods

A total of 29,585 convalescent plasma donors employed during the first and second waves of the COVID-19 pandemic in England were included in this study. All had been tested for SARS-CoV-2 IgG antibodies by EUROimmun ELISA. A multivariable logistic regression model was used to quantify the association of the demographic and clinical factors with

SUBMITTER: Mehew J 

PROVIDER: S-EPMC9115414 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature