Buprenorphine Exposure Alters the Development and Migration of Interneurons in the Cortex.

ABSTRACT: The misuse of opioids has reached epidemic proportions over the last decade, with over 2.1 million people in the United States suffering from substance use disorders related to prescription opioid pain relievers. This increase in opioid misuse affects all demographics of society, including women of child-bearing age, which has led to a rise in opioid use during pregnancy. Opioid use during pregnancy has been associated with increased risk of obstetric complications and adverse neonatal outcomes, including neonatal abstinence syndrome. Currently, opioid use disorder in pregnant women is treated with long-acting opioid agonists, including buprenorphine. Although buprenorphine reduces illicit opioid use during pregnancy and improves infant outcomes at birth, few long-term studies of the neuro

SUBMITTER: Nieto-Estevez V 

PROVIDER: S-EPMC9115473 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature