Comprehensive Analysis of the Expression and Prognosis for RAD51 Family in Human Breast Cancer.

ABSTRACT:

Purpose

The RAD51 family of genes, including RAD51 and the five RAD51-like paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3), are known to be crucially associated with DNA damage repair pathway. Increasing evidence indicated that RAD51 family members were implicated in breast cancer tumorigenesis. However, their biological roles and prognostic values in breast cancer have yet to be clarified.

Methods

In this study, by using the Oncomine and GEPIA databases, we explored the transcriptional levels of RAD51 family members in breast cancer. Besides, the associations between RAD51 family expression and clinical features were evaluated by using the UALCAN database and Kaplan-Meier (KM) Plotter. We also analyzed the mutations of the RAD51 family and differentially altered genes f

SUBMITTER: Shi Y 

PROVIDER: S-EPMC9115836 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature