Addressing Regional Differences in Diabetes Progression: Global Calibration for Diabetes Simulation Model.

ABSTRACT:

Objectives

To develop a practical solution for modeling diabetes progression and account for the variations in risks of diabetes complications in different regions of the world, which is critical for model-based evaluations on the value of diabetes intervention across populations from different regions globally.

Methods

A literature search was conducted to identify eligible clinical trials to support calibration. The Building, Relating, Assessing, and Validating Outcomes (BRAVO) model was employed to simulate diabetes complications using the baseline characteristics of each clinical trial cohort. We utilized regression methods to estimate regional variations across the United States, Europe, Asia, and other regions (eg, Latin America, Africa) in 6 outcomes: myocardial infarc

SUBMITTER: Shao H 

PROVIDER: S-EPMC9115837 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature