Malaria Chemoprevention in the Postdischarge Management of Severe Anemia.

ABSTRACT:

Background

Children who have been hospitalized with severe anemia in areas of Africa in which malaria is endemic have a high risk of readmission and death within 6 months after discharge. No prevention strategy specifically addresses this period.

Methods

We conducted a multicenter, two-group, randomized, placebo-controlled trial in nine hospitals in Kenya and Uganda to determine whether 3 months of malaria chemoprevention could reduce morbidity and mortality after hospital discharge in children younger than 5 years of age who had been admitted with severe anemia. All children received standard in-hospital care for severe anemia and a 3-day course of artemether-lumefantrine at discharge. Two weeks after discharge, children were randomly assigned to receive dihydroartemisinin-

SUBMITTER: Kwambai TK 

PROVIDER: S-EPMC9115866 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature