Immune correlates of cardiovascular co-morbidity in HIV infected participants from South India.

ABSTRACT:

Background

Understanding the immune correlates of cardiovascular disease (CVD) risk in HIV infection is an important area of investigation in the current era of aging with HIV infection. Less is known about CVD risk and HIV infection in developing nations where additional risk factors may be playing a role in the CVD development. In this study, we assessed the effects of systemic inflammation, microbial translocation (MT), T cell immune activation (IA), and nadir CD4 counts on cardiac function and arterial stiffness as markers of subclinical atherosclerosis in HIV-infected individuals.

Methods

People with HIV (PWH) who were ART naïve (n = 102) or virally suppressed on ART (n = 172) were stratified on nadir CD4 counts and compared to HIV-uninfected controls (n = 64). Determin

SUBMITTER: Kausalya B 

PROVIDER: S-EPMC9115939 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature