Design, synthesis, and bioactivity of ferulic acid derivatives containing an β-amino alcohol.

ABSTRACT:

Background

Plant diseases caused by viruses and bacteria cause huge economic losses due to the lack of effective control agents. New potential pesticides can be discovered through biomimetic synthesis and structural modification of natural products. A series of ferulic acid derivatives containing an β-amino alcohol were designed and synthesized, and their biological activities were evaluated.

Result

Bioassays results showed that the EC₅₀ values of compound D24 against Xanthomonas oryzae pv. oryzae (Xoo) was 14.5 μg/mL, which was better than that of bismerthiazol (BT, EC₅₀ = 16.2 μg/mL) and thiodiazole copper (TC, EC₅₀ = 44.5 μg/mL). The in vivo curative and protective activities of compound D24 against Xoo were 50.5% and 50.1%, respectively.

SUBMITTER: Dai A 

PROVIDER: S-EPMC9115944 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature