Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort.

ABSTRACT:

Background

This work aimed to investigate the potential pathways involved in the association between social and lifestyle factors, biomarkers of Alzheimer's disease and related dementia (ADRD), and cognition.

Methods

The authors studied 2323 participants from the Memento study, a French nationwide clinical cohort. Social and lifestyle factors were education level, current household incomes, physical activity, leisure activities, and social network from which two continuous latent variables were computed: an early to midlife (EML) and a latelife (LL) indicator. Brain magnetic resonance imaging (MRI), lumbar puncture, and amyloid-positron emission tomography (PET) were used to define three latent variables: neurodegeneration, small vessel disease (SVD), and AD pathology. Cogni

SUBMITTER: Grasset L 

PROVIDER: S-EPMC9115948 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature