Prioritising attributes for tuberculosis preventive treatment regimens: a modelling analysis.

ABSTRACT:

Background

Recent years have seen important improvements in available preventive treatment regimens for tuberculosis (TB), and research is ongoing to develop these further. To assist with the formulation of target product profiles for future regimens, we examined which regimen properties would be most influential in the epidemiological impact of preventive treatment.

Methods

Following expert consultation, we identified 5 regimen properties relevant to the incidence-reducing impact of a future preventive treatment regimen: regimen duration, efficacy, ease-of-adherence (treatment completion rates in programmatic conditions), forgiveness to non-completion and the barrier to developing rifampicin resistance during treatment. For each regimen property, we elicited expert input fo

SUBMITTER: Vesga JF 

PROVIDER: S-EPMC9115962 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature