Dataset Information

Association of acute kidney disease with the prognosis of ischemic stroke in the Third China National Stroke Registry.

ABSTRACT:

Background

Acute kidney disease (AKD) evolves a spectrum of acute and subacute kidney disease requiring a global strategy to address. The present study aimed to explore the impact of AKD on the prognosis of ischemic stroke.

Methods

The Third China National Stroke Registry (CNSR-III) was a nationwide registry of ischemic stroke or transient ischemic attack between August 2015 and March 2018. As a subgroup of CNSR-III, the patients who had serum creatinine (sCr) and serum cystatin C (sCysC) centrally tested on admission and at 3-month, and with 1-year follow-up data were enrolled. Modified AKD criteria were applied to identify patients with AKD during the first 3 months post stroke according to the guidelines developed by the Kidney Disease: Improving Global Outcomes in 2012. The primary clinical outcome was 1-year all-cause death, and secondary outcomes were stroke recurrence and post stroke disability.

Results

Five thousand sixty-five patients were recruited in the study. AKD was identified in 3.9%, 6.7%, 9.9% and 6.2% of the patients by using sCr, sCr-based estimated glomerular filtration rate (eGFR_sCr), sCysC-based eGFR (eGFR_sCysC), and combined sCr and sCysC-based eGFR (eGFR_sCr+sCysC) criteria, respectively. AKD defined as sCr or eGFR_sCr criteria significantly increased the risk of all-cause mortality (adjusted HR 2.67, 95% CI: 1.27-5.61; adjusted HR 2.19, 95% CI: 1.17-4.10) and post stroke disability (adjusted OR 1.60, 95% CI: 1.04-2.44; adjusted OR 1.51, 95% CI: 1.08-2.11). AKD diagnosed by eGFR_sCysC or eGFR_sCr+sCysC criteria had no significant impact on the risk of all-cause death and post stroke disability. AKD, defined by whichever criteria, was not associated with the risk of stroke recurrence in the adjusted model.

Conclusions

AKD, diagnosed by sCr or eGFR_sCr criteria, were independently associated with 1-year all-cause death and post stroke disability in Chinese ischemic stroke patients.

SUBMITTER: Zhou Y

PROVIDER: S-EPMC9115968 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Association of acute kidney disease with the prognosis of ischemic stroke in the Third China National Stroke Registry.

Zhou Yilun Y Wang Dongxue D Li Hao H Pan Yuesong Y Xiang Xianglong X Wu Yu Y Xie Xuewei X Wang Xianwei X Luo Yang Y Meng Xia X Lin Jinxi J Wang Hong H Huo Yong Y Matsushita Kunihiro K Chen Jing J Hou Fan Fan FF Wang Yongjun Y

BMC nephrology 20220518 1

<h4>Background</h4>Acute kidney disease (AKD) evolves a spectrum of acute and subacute kidney disease requiring a global strategy to address. The present study aimed to explore the impact of AKD on the prognosis of ischemic stroke.<h4>Methods</h4>The Third China National Stroke Registry (CNSR-III) was a nationwide registry of ischemic stroke or transient ischemic attack between August 2015 and March 2018. As a subgroup of CNSR-III, the patients who had serum creatinine (sCr) and serum cystatin C ...[more]

PMID: 35585568

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Project description:Background and purposeConflicting reports of obesity paradox have led to confusion about weight management strategies for post-stroke patients. The main purpose of this study is to determine whether the obesity paradox measured by body mass index (BMI) or by waist-to-height ratio (WHtR) is real.MethodsWe evaluated the association of general obesity measured by BMI, and abdominal obesity measured by WHtR with 1-year all-cause mortality, recurrence of stroke and combined vascular events of acute ischemic stroke (AIS) patients in a cohort -- the Third China National Stroke Registry (CNSR-III). Cox proportional hazards models and restricted cubic splines were performed to investigate the association between obesity and clinical outcomes.ResultsA total of 14,146 patients with ischemic stroke were included. When BMI was used as a measure of obesity, compared to the normal weight patients, mortality decreased in overweight patients (hazard ratio [HR] 0.74 [95% confidence interval (CI) 0.61-0.91], P = 0.0035) and obese patients (HR 0.54 [0.40-0.73], P < 0.0001); and increased in underweight patients (HR 2.55 [1.75-3.73], P < 0.0001). After adjustment for confounding factors, the protective effect of obesity and overweight disappeared. BMI had no association with recurrence of stroke or combined vascular events. When WHtR was used as a measure of obesity, obese patients had lower 1-year all-cause mortality (HR 0.64 [0.43-0.97], P = 0.0357). After adjustment for confounding factors, this difference disappeared; overweight patients still had lower all-cause mortality (adjusted hazard ratio [aHR] 0.42 [0.26-0.67], P = 0.0003), recurrence of stroke (aHR 0.77 [0.60-0.99], P = 0.0440) and combined vascular events (aHR 0.75 [0.58-0.95], P = 0.0198).ConclusionsAmong Chinese patients with AIS, our study does not support the BMI paradox; overweight patients measured by WHtR had a more favorable prognosis. TOAST subtypes did not modify the association.

Dataset Information

Association of acute kidney disease with the prognosis of ischemic stroke in the Third China National Stroke Registry.

Background

Methods

Results

Conclusions

Publications

Association of acute kidney disease with the prognosis of ischemic stroke in the Third China National Stroke Registry.

Similar Datasets

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