Dataset Information

Ocular adnexal lymphoma: A single-institution retrospective study.

ABSTRACT:

Purpose

To characterize demographic, clinical, and histopathologic features of ocular adnexal lymphoma (OAL) at a single institution.

Methods

Retrospective review of all patients with pathologic diagnosis of OAL between 2015 and 2020.

Results

There were 133 patients with OAL, with a median age of 65 years (range 23-97) and a slight female predominance (male: female = 1:1.46), (n = 79, 59%). The majority of tumors were non-Hodgkin B-cell lymphomas (n = 131, 99%), most frequently Extranodal Marginal Zone B-Cell Lymphoma (EMZL, n = 93, 70%), followed by follicular lymphoma (n = 21, 16%), chronic lymphocytic leukemia/small lymphocytic lymphoma (n = 7, 5%), diffuse large B-cell lymphoma (n = 5, 4%), and mantle cell lymphoma (n = 5, 4%). The most frequently involved sites included the orbit (n = 85, 64%) and conjunctiva (n = 43, 32%). Information was available on oncologic staging in 78 (59%), treatment in 82 (62%), and follow-up in 75 (56%) patients. By the Ann-Arbor classification system, patients were classified as IE (54/78, 69%), IIE (9/78, 12%), IIIE (6/78, 8%), and IVE (9/78, 12%). The most common treatments included external beam radiotherapy (standard and ultra-low-dose) (48/82, 59%), biologics (22/82, 27%), and surgical excision with cryotherapy (14/82, 17%) (some patients had >1 therapy). Median follow-up time was 24 months (range 0-221 months). Recurrence was observed in 13% (10/75) with a median time to recurrence of 60 months (95% confidence interval 47-73 months). Excision with cryotherapy as a sole treatment modality was associated with earlier recurrence (P = 0.003).

Conclusion

In this largest single-center study of OAL, we found that most OAL were Ann-Arbor Stage IE EMZL, occurring in older patients with a female predominance. Early recurrence was noted in tumors treated with excision and cryotherapy alone.

SUBMITTER: Fernandez CA

PROVIDER: S-EPMC9116088 | biostudies-literature | 2021 Jul-Sep

REPOSITORIES: biostudies-literature

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Publications

Ocular adnexal lymphoma: A single-institution retrospective study.

Fernández César A CA Henry Roger K RK Shields Carol L CL Bilyk Jurij R JR Lally Sara E SE Eagle Ralph C RC Milman Tatyana T

Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society 20210701 3

<h4>Purpose</h4>To characterize demographic, clinical, and histopathologic features of ocular adnexal lymphoma (OAL) at a single institution.<h4>Methods</h4>Retrospective review of all patients with pathologic diagnosis of OAL between 2015 and 2020.<h4>Results</h4>There were 133 patients with OAL, with a median age of 65 years (range 23-97) and a slight female predominance (male: female = 1:1.46), (<i>n</i> = 79, 59%). The majority of tumors were non-Hodgkin B-cell lymphomas (<i>n</i> = 131, 99% ...[more]

PMID: 35601857

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Dataset Information

Ocular adnexal lymphoma: A single-institution retrospective study.

Purpose

Methods

Results

Conclusion

Publications

Ocular adnexal lymphoma: A single-institution retrospective study.

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