Klotho Polymorphism in Association With Serum Testosterone and Knee Strength in Women After Testosterone Administration.

ABSTRACT: Administration of testosterone (T) is associated with increased serum T concentrations and improved physical performance in women. However, the inter-individual variation in T concentrations after T treatment is large and may in part be due to genetic variations. Serum T, as well as dihydrotestosterone (DHT), androstenedione (A) and the T/A ratio have been suggested as promising doping biomarkers for testosterone intake. Here, polymorphisms in androgen metabolic enzyme genes have been investigated in healthy women prior to and after 10 weeks administration of testosterone cream. Klotho is a protein that has been associated with anaerobic strength and here a genetic variation in klotho gene was studied in relation to performance as measured by isokinetic knee strength, as well as to serum a

SUBMITTER: Ekstrom L 

PROVIDER: S-EPMC9116293 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature