Transport of Maternally Administered Pharmaceutical Agents Across the Placental Barrier In Vitro.

ABSTRACT: To understand the transport of pharmaceutical agents and their effects on developing fetus, we have created a placental microsystem that mimics structural phenotypes and physiological characteristic of a placental barrier. We have shown the formation of a continuous network of epithelial adherens junctions and endothelial cell-cell junctions confirming the integrity of the placental barrier. More importantly, the formation of elongated microvilli under dynamic flow condition is demonstrated. Fluid shear stress acts as a mechanical cue triggering the microvilli formation. Pharmaceutical agents were administered to the maternal channel, and the concentration of pharmaceutical agents in fetal channel for coculture and control models were evaluated. In fetal channel, the coculture model exhibi

SUBMITTER: Pemathilaka RL 

PROVIDER: S-EPMC9116385 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature