Two-part joint model for a longitudinal semicontinuous marker and a terminal event with application to metastatic colorectal cancer data.

ABSTRACT: Joint models for a longitudinal biomarker and a terminal event have gained interests for evaluating cancer clinical trials because the tumor evolution reflects directly the state of the disease. A biomarker characterizing the tumor size evolution over time can be highly informative for assessing treatment options and could be taken into account in addition to the survival time. The biomarker often has a semicontinuous distribution, i.e., it is zero inflated and right skewed. An appropriate model is needed for the longitudinal biomarker as well as an association structure with the survival outcome. In this article, we propose a joint model for a longitudinal semicontinuous biomarker and a survival time. The semicontinuous nature of the longitudinal biomarker is specified by a two-part model

SUBMITTER: Rustand D 

PROVIDER: S-EPMC9116390 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature