Integrative multiomics analysis reveals host-microbe-metabolite interplays associated with the aging process in Singaporeans.

ABSTRACT: The age-associated alterations in microbiomes vary across populations due to the influence of genetics and lifestyles. To the best of our knowledge, the microbial changes associated with aging have not yet been investigated in Singapore adults. We conducted shotgun metagenomic sequencing of fecal and saliva samples, as well as fecal metabolomics to characterize the gut and oral microbial communities of 62 healthy adult male Singaporeans, including 32 young subjects (age, 23.1 ± 1.4 years) and 30 elderly subjects (age, 69.0 ± 3.5 years). We identified 8 gut and 13 oral species that were differentially abundant in elderly compared to young subjects. By combining the gut and oral microbiomes, 25 age-associated oral-gut species connections were identified. Moreover, oral bacteria Acidaminoc

SUBMITTER: Chen L 

PROVIDER: S-EPMC9116421 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature