Generation of functional fat organoid from rat superficial fascia.

ABSTRACT: The organoid is a 3D cell architecture formed by self-organized tissues or cells in vitro with similar cell types, histological structures, and biological functions of the native organ. Depending on the unique organ structures and cell types, the production of organoids requires individualized design and is still challenging. Organoids of some organs and tissues, including adipose tissue, remain to generate to be more faithful to their original organ in structure and function. We previously established a new model of the origin of adipose cells originating from non-adipose fascia tissue. Superficial fascia has abundant preadipocytes that are capable of adipogenic differentiation and are highly active in vivo. Here, we investigated superficial fascia fragments in 3D hydrogel a

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9116422 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature