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Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review.

ABSTRACT: This paper aims to provide an important update on the recent preclinical and clinical trials using cell therapy strategies and engineered heart tissues for the treatment of postinfarction left ventricular remodeling and heart failure. In addition to the authors' own works and opinions on the roadblocks of the field, they discuss novel approaches for cardiac remuscularization via the activation of proliferative mechanisms in resident cardiomyocytes or direct reprogramming of somatic cells into cardiomyocytes. This paper's main mindset is to present current and future strategies in light of their implications for the design of future patient trials with the ultimate objective of facilitating the translation of discoveries in regenerative myocardial therapies to the clinic.

SUBMITTER: Zhang J

PROVIDER: S-EPMC9116459 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review.

Zhang Jianyi J Bolli Roberto R Garry Daniel J DJ Marbán Eduardo E Menasché Philippe P Zimmermann Wolfram-Hubertus WH Kamp Timothy J TJ Wu Joseph C JC Dzau Victor J VJ

Journal of the American College of Cardiology 20211101 21

This paper aims to provide an important update on the recent preclinical and clinical trials using cell therapy strategies and engineered heart tissues for the treatment of postinfarction left ventricular remodeling and heart failure. In addition to the authors' own works and opinions on the roadblocks of the field, they discuss novel approaches for cardiac remuscularization via the activation of proliferative mechanisms in resident cardiomyocytes or direct reprogramming of somatic cells into ca ...[more]

PMID: 34794691

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