Measuring conductance switching in single proteins using quantum tunneling.

ABSTRACT: Interpreting the electrical signatures of single proteins in electronic junctions has facilitated a better understanding of the intrinsic properties of proteins that are fundamental to chemical and biological processes. Often, this information is not accessible using ensemble and even single-molecule approaches. In addition, the fabrication of nanoscale single-protein junctions remains challenging as they often require sophisticated methods. We report on the fabrication of tunneling probes, direct measurement, and active control (switching) of single-protein conductance with an external field in solution. The probes allowed us to bridge a single streptavidin molecule to two independently addressable, biotin-terminated electrodes and measure single-protein tunneling response over long perio

SUBMITTER: Tang L 

PROVIDER: S-EPMC9116604 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature