Spatial dynamics of feedback and feedforward regulation in cell lineages.

ABSTRACT: Feedback mechanisms within cell lineages are thought to be important for maintaining tissue homeostasis. Mathematical models that assume well-mixed cell populations, together with experimental data, have suggested that negative feedback from differentiated cells on the stem cell self-renewal probability can maintain a stable equilibrium and hence homeostasis. Cell lineage dynamics, however, are characterized by spatial structure, which can lead to different properties. Here, we investigate these dynamics using spatially explicit computational models, including cell division, differentiation, death, and migration / diffusion processes. According to these models, the negative feedback loop on stem cell self-renewal fails to maintain homeostasis, both under the assumption of strong spatial re

SUBMITTER: Uhl P 

PROVIDER: S-EPMC9116666 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature