Xprediction: Explainable EGFR-TKIs response prediction based on drug sensitivity specific gene networks.

ABSTRACT: In recent years, drug sensitivity prediction has garnered a great deal of attention due to the growing interest in precision medicine. Several computational methods have been developed for drug sensitivity prediction and the identification of related markers. However, most previous studies have ignored genetic interaction, although complex diseases (e.g., cancer) involve many genes intricately connected in a molecular network rather than the abnormality of a single gene. To effectively predict drug sensitivity and understand its mechanism, we propose a novel strategy for explainable drug sensitivity prediction based on sample-specific gene regulatory networks, designated Xprediction. Our strategy first estimates sample-specific gene regulatory networks that enable us to identify the molecu

SUBMITTER: Park H 

PROVIDER: S-EPMC9116684 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature