Polygenic score accuracy in ancient samples: Quantifying the effects of allelic turnover.

ABSTRACT: Polygenic scores link the genotypes of ancient individuals to their phenotypes, which are often unobservable, offering a tantalizing opportunity to reconstruct complex trait evolution. In practice, however, interpretation of ancient polygenic scores is subject to numerous assumptions. For one, the genome-wide association (GWA) studies from which polygenic scores are derived, can only estimate effect sizes for loci segregating in contemporary populations. Therefore, a GWA study may not correctly identify all loci relevant to trait variation in the ancient population. In addition, the frequencies of trait-associated loci may have changed in the intervening years. Here, we devise a theoretical framework to quantify the effect of this allelic turnover on the statistical properties of polygenic

SUBMITTER: Carlson MO 

PROVIDER: S-EPMC9116686 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature