No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan.

ABSTRACT:

Background

The potential risk and association of bovine leukemia virus (BLV) with human remains controversial as it has been reported to be both positive and negative in human breast cancer and blood samples. Therefore, establishing the presence of BLV in comprehensive human clinical samples in different geographical locations is essential.

Result

In this study, we examined the presence of BLV proviral DNA in human blood and breast cancer tissue specimens from Japan. PCR analysis of BLV provirus in 97 Japanese human blood samples and 23 breast cancer tissues showed negative result for all samples tested using long-fragment PCR and highly-sensitive short-fragment PCR amplification. No IgG and IgM antibodies were detected in any of the 97 human serum samples using BLV gp51 and

SUBMITTER: Yamanaka MP 

PROVIDER: S-EPMC9116711 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature