Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions.

ABSTRACT: Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and immunosuppressive therapeutics in the 1940s and their continued use and development have successfully revolutionized the management of acute and chronic inflammatory diseases. However, long-term use of glucocorticoids is severely hampered by undesirable metabolic complications, including the development of type 2 diabetes mellitus. These effects occur due to glucocorticoid receptor activation within multiple tissues, which results in inter-organ crosstalk that increases hepatic glucose production and inhibits peripheral glucose uptake. Despite the high prevalence of glucocorticoid-induced hyperglycaemia associated with their routine clinical use, treatment protocols for optimal management of the metabolic a

SUBMITTER: Li JX 

PROVIDER: S-EPMC9116713 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature