DR1 Activation Inhibits the Proliferation of Vascular Smooth Muscle Cells through Increasing Endogenous H₂S in Diabetes.

ABSTRACT: Tissue ischemia and hypoxia caused by the abnormal proliferation of smooth muscle cells (SMCs) in the diabetic state is an important pathological basis for diabetic microangiopathy. Studies in recent years have shown that the chronic complications of diabetes are related to the decrease of endogenous hydrogen sulfide (H₂S) in diabetic patients, and it has been proven that H₂S can inhibit the proliferation of vascular SMCs (VSMCs). Our study showed that the endogenous H₂S content and the expression of cystathionine gamma-lyase (CSE), which is the key enzyme of H₂S production, were decreased in arterial SMCs of diabetic mice. The expression of PCNA and Cyclin D1 was increased, and the expression of p21 was decreased in the diabetic state. After adm

SUBMITTER: Xi Y 

PROVIDER: S-EPMC9116912 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature