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Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants.

ABSTRACT: The different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have attracted most public concern because they caused "wave and wave" COVID-19 pandemic. The initial step of viral infection is mediated by the SARS-CoV-2 Spike (S) protein, which mediates the receptor recognition and membrane fusion between virus and host cells. Neutralizing antibodies (nAbs) targeting the S protein of SARS-CoV-2 have become promising candidates for clinical intervention strategy, while multiple studies have shown that different variants have enhanced infectivity and antibody resistance. Here, we explore the structure and function of STS165, a broadly inter-Spike bivalent nAb against SARS-CoV-2 variants and even SARS-CoV, contributing to further understanding of the working mechanism of nAbs.

SUBMITTER: Li Y

PROVIDER: S-EPMC9116965 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants.

Li Yaning Y Fan Qing Q Zhou Bing B Shen Yaping Y Zhang Yuanyuan Y Cheng Lin L Qi Furong F Song Shuo S Guo Yingying Y Yan Renhong R Ju Bin B Zhang Zheng Z

iScience 20220518 6

The different variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have attracted most public concern because they caused "wave and wave" COVID-19 pandemic. The initial step of viral infection is mediated by the SARS-CoV-2 Spike (S) protein, which mediates the receptor recognition and membrane fusion between virus and host cells. Neutralizing antibodies (nAbs) targeting the S protein of SARS-CoV-2 have become promising candidates for clinical intervention strategy, while mult ...[more]

PMID: 35607524

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