Quantifying the duration of the preclinical detectable phase in cancer screening: a systematic review.

ABSTRACT:

Objectives

The aim of this study was to provide an overview of published mathematical estimation approaches to quantify the duration of the preclinical detectable phase (PCDP) using data from cancer screening programs.

Methods

A systematic search of PubMed and Embase was conducted for original studies presenting mathematical approaches using screening data. The studies were categorized by mathematical approach, data source, and assumptions made. Furthermore, estimates of the duration of the PCDP of breast and colorectal cancer were reported per study population.

Results

From 689 publications, 34 estimation methods were included. Five distinct types of mathematical estimation approaches were identified: prevalence-to-incidence ratio (n=8), maximum likelihood estimation

SUBMITTER: Geurts SME 

PROVIDER: S-EPMC9117108 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature