Unknown

Dataset Information

0

Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants.


ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant is highly transmissible with potential immune escape. We conducted a test-negative case-control study to evaluate mRNA-1273 vaccine effectiveness (VE) against infection and hospitalization with Omicron or Delta. The large, diverse study population included 26,683 SARS-CoV-2 test-positive cases with variants determined by S gene target failure status (16% Delta and 84% Omicron). The two-dose VE against Omicron infection at 14-90 days was 44.0% (95% confidence interval, 35.1-51.6%) but declined quickly. The three-dose VE was 93.7% (92.2-94.9%) and 86.0% (78.1-91.1%) against Delta infection and 71.6% (69.7-73.4%) and 47.4% (40.5-53.5%) against Omicron infection at 14-60 days and >60 days, respectively. The three-dose VE was 29.4% (0.3-50.0%) against Omicron infection in immunocompromised individuals. The three-dose VE against hospitalization with Delta or Omicron was >99% across the entire study population. Our findings demonstrate high, durable three-dose VE against Delta infection but lower effectiveness against Omicron infection, particularly among immunocompromised people. However, three-dose VE of mRNA-1273 was high against hospitalization with Delta and Omicron variants.

SUBMITTER: Tseng HF 

PROVIDER: S-EPMC9117141 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

altmetric image

Publications


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant is highly transmissible with potential immune escape. We conducted a test-negative case-control study to evaluate mRNA-1273 vaccine effectiveness (VE) against infection and hospitalization with Omicron or Delta. The large, diverse study population included 26,683 SARS-CoV-2 test-positive cases with variants determined by S gene target failure status (16% Delta and 84% Omicron). The two-dose VE against Omicro  ...[more]

Similar Datasets

| S-EPMC8671836 | biostudies-literature
| S-EPMC8142657 | biostudies-literature
| S-EPMC8809505 | biostudies-literature
| S-EPMC8691522 | biostudies-literature
| S-EPMC8687471 | biostudies-literature
| S-EPMC8784612 | biostudies-literature
| S-EPMC8664708 | biostudies-literature
| S-EPMC9261010 | biostudies-literature
| S-EPMC8809504 | biostudies-literature
| S-EPMC8552536 | biostudies-literature