ErbB4 in parvalbumin-positive interneurons mediates proactive interference in olfactory associative reversal learning.

ABSTRACT: Consolidated memories influence later learning and cognitive processes when new information is overlapped with previous events. To reveal which cellular and molecular factors are associated with this proactive interference, we challenged mice with odor-reward associative learning followed by a reversal-learning task. The results showed that genetical ablation of ErbB4 in parvalbumin (PV)-positive interneurons improved performance in reversal-learning phase, with no alteration in learning phase, supporting that PV interneuron ErbB4 is required for proactive interference. Mechanistically, olfactory learning promoted PV interneuron excitatory synaptic plasticity and direct binding of ErbB4 with presynaptic Neurexin1β (NRXN1β) and postsynaptic scaffold PSD-95 in the prefrontal cortex. Interrup

SUBMITTER: Xu Y 

PROVIDER: S-EPMC9117204 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature