Economic choice between remifentanil and food in squirrel monkeys.

ABSTRACT: Traditional approaches for evaluating if compounds are reinforcing, and thus a risk for abuse, include preclinical self-administration procedures conducted in the absence of alternative reinforcers. While the track record of this approach for determining abuse potential is good, that for predicting efficacy of addiction treatments is not. An alternate approach would be economic choice between drug and nondrug rewards, with parametrically varied options from trial to trial. This would promote goal-directed decisions between reward modalities and should provide metrics that reflect changes in internal state that influence desirability of a given option. We report herein a high throughput economic choice procedure in which squirrel monkeys choose between a short-lived opiate, remifentanil, an

SUBMITTER: Brown SO 

PROVIDER: S-EPMC9117236 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature