Sustainable Thioetherification via Electron Donor-Acceptor Photoactivation Using Thianthrenium Salts.

ABSTRACT: The synthesis of sulfides has been widely studied because this functional subunit is prevalent in biomolecules and pharmaceuticals, as well as being a useful synthetic platform for further elaboration. Thus, various methods to build C-S bonds have been developed, but typically they require the use of precious metals or harsh conditions. Electron donor-acceptor (EDA) complex photoactivation strategies have emerged as versatile and sustainable ways to achieve C-S bond formation, avoiding challenges associated with previous methods. This work describes an open-to-air, photoinduced, site-selective C-H thioetherification from readily available reagents via EDA complex formation that tolerates a wide range of different functional groups. Moreover, C(sp² )-halogen bonds remain intact u

SUBMITTER: Cabrera-Afonso MJ 

PROVIDER: S-EPMC9117462 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature