Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood.

ABSTRACT:

Background

Binge alcohol exposure during adolescence results in long-lasting alterations in the brain and behavior. For example, adolescent intermittent ethanol (AIE) exposure in rodents results in long-term loss of functional connectivity among prefrontal cortex (PFC) and striatal regions as well as a variety of neurochemical, molecular, and epigenetic alterations. Interneurons in the PFC and striatum play critical roles in behavioral flexibility and functional connectivity. For example, parvalbumin (PV) interneurons are known to contribute to neural synchrony and cholinergic interneurons contribute to strategy selection. Furthermore, extracellular perineuronal nets (PNNs) that surround some interneurons, particularly PV+ interneurons, further regulate cellular plasticity. The eff

SUBMITTER: Dannenhoffer CA 

PROVIDER: S-EPMC9117471 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature