Predicting 10-year survival after resection of colorectal liver metastases; an international study including biomarkers and perioperative treatment.

ABSTRACT:

Background

The aim of this study was to develop a prediction model for 10-year overall survival (OS) after resection of colorectal liver metastasis (CRLM) based on patient, tumour and treatment characteristics.

Methods

Consecutive patients after complete resection of CRLM were included from two centres (1992-2019). A prediction model providing 10-year OS probabilities was developed using Cox regression analysis, including KRAS, BRAF and histopathological growth patterns. Discrimination and calibration were assessed using cross-validation. A web-based calculator was built to predict individual 10-year OS probabilities.

Results

A total of 4112 patients were included. The estimated 10-year OS was 30% (95% CI 29-32). Fifteen patient, tumour and treatment characteristics w

SUBMITTER: Buisman FE 

PROVIDER: S-EPMC9117473 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature