Postprandial Plasma Lipidomics Reveal Specific Alteration of Hepatic-derived Diacylglycerols in Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Background & aims

Hepatic energy metabolism is a dynamic process modulated by multiple stimuli. In nonalcoholic fatty liver disease (NAFLD), human studies typically focus on the static fasting state. We hypothesized that unique postprandial alterations in hepatic lipid metabolism are present in NAFLD.

Methods

In a prospective clinical study, 37 patients with NAFLD and 10 healthy control subjects ingested a standardized liquid meal with pre- and postprandial blood sampling. Postprandial plasma lipid kinetics were characterized at the molecular lipid species level by untargeted lipidomics, cluster analysis, and lipid particle isolation, then confirmed in a mouse model.

Results

There was a specific increase of multiple plasma diacylglycerol (DAG) species at 4 hours postp

SUBMITTER: Velenosi TJ 

PROVIDER: S-EPMC9117487 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature