Relationship between periodontitis and psoriasis: A two-sample Mendelian randomization study.

ABSTRACT:

Aim

Observational research suggests that periodontitis affects psoriasis. However, observational studies are prone to reverse causation and confounding, which hampers drawing causal conclusions and the effect direction. We applied the Mendelian randomization (MR) method to comprehensively assess the potential bi-directional association between periodontitis and psoriasis.

Materials and methods

We used genetic instruments from the largest available genome-wide association study of European descent for periodontitis (17,353 cases, 28,210 controls) to investigate the relationship with psoriasis (13,229 cases, 21,543 controls), and vice versa. Causal Analysis Using Summary Effect (CAUSE) estimates and inverse variance-weighted (IVW) MR analyses were used for the primary analysis

SUBMITTER: Baurecht H 

PROVIDER: S-EPMC9117489 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature