Degron-mediated proteolysis of CrhR-like DEAD-box RNA helicases in cyanobacteria.

ABSTRACT: Conditional proteolytic degradation is an irreversible and highly regulated process that fulfills crucial regulatory functions in all organisms. As proteolytic targets tend to be critical metabolic or regulatory proteins, substrates are targeted for degradation only under appropriate conditions through the recognition of an amino acid sequence referred to as a "degron". DEAD-box RNA helicases mediate all aspects of RNA metabolism, contributing to cellular fitness. However, the mechanism by which abiotic-stress modulation of protein stability regulates bacterial helicase abundance has not been extensively characterized. Here, we provide in vivo evidence that proteolytic degradation of the cyanobacterial DEAD-box RNA helicase CrhR is conditional, being initiated by a temperature upshift from

SUBMITTER: Whitman BT 

PROVIDER: S-EPMC9117542 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature